CML Blast Crisis treatment - Chronic myeloid leukemia
Blast crisis (BC) remains the major challenge in the management of chronic myeloid leukemia (CML).
CLINICAL TRIALS
Clinical Trial of BP1001 (Liposomal Grb2 Antisense Oligonucleotide) in Combination With Dasatinib in Patients With Ph + CML
Axitinib and Bosutinib for Patients With Chronic Myeloid Leukemia in Chronic, Accelerated or Blastic Phases
An Open-Label, Phase I/II Study of Two Different Schedules of Dasatinib (Sprycel) and Decitabine (Dacogen) Used in Combination for Patients With Accelerated or Blastic Phase Chronic Myelogenous Leukemia (Protocol CA180357)
Evaluation of ETC-1907206 With Dasatinib in Advanced Haematologic Malignancies
Clinical Trial of BP1001 (Liposomal Grb2 Antisense Oligonucleotide) in Combination With Dasatinib in Patients With Ph + CML
Axitinib and Bosutinib for Patients With Chronic Myeloid Leukemia in Chronic, Accelerated or Blastic Phases
An Open-Label, Phase I/II Study of Two Different Schedules of Dasatinib (Sprycel) and Decitabine (Dacogen) Used in Combination for Patients With Accelerated or Blastic Phase Chronic Myelogenous Leukemia (Protocol CA180357)
Evaluation of ETC-1907206 With Dasatinib in Advanced Haematologic Malignancies
VIDEOS
Blast Crisis in CML | When Chronic Myeloid Leukemia Goes Mad!
August 17, 2018, Medicosis Perfectionalis
Blast Crisis in CML | When Chronic Myeloid Leukemia Goes Mad!
August 17, 2018, Medicosis Perfectionalis
ARTICLES
Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia
February 4, 2022, Leukemia
Matchpoint: the game is not over for blast-phase chronic myeloid leukaemia
February 2, 2022, The Lancet Haematology
Understanding and Monitoring Chronic Myeloid Leukemia Blast Crisis: How to Better Manage Patients
June 23, 2021, DovePress
Common therapeutic vulnerability for a genetically diverse and deadly leukemia
March 18, 2020, Science Daily
Researchers in Singapore find common therapeutic vulnerability for a genetically diverse and deadly leukaemia
March 17, 2020, DUKE NUS Medical School
An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
March 10, 2020, Journal Blood
Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia
February 20, 2020, Leukemia
Blast count prognostic for CML presenting in advanced phase
September 26, 2019, Medical Xpress
Pre- and post-transplant ponatinib for a patient with acute megakaryoblastic blast phase chronic myeloid leukemia with T315I mutation who underwent allogeneic hematopoietic stem cell transplantation
March 16, 2019, PubMed
TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML
April 4, 2017, NCBI
Researchers identify factors associated with survival in patients with blast phase CML
February 24, 2017, Healio
Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia
February 24, 2017, Leukemia
TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML
February 18, 2017, NCBI
MS4A3: A New Player in Leukemic Stem Cell Survival in Chronic Myeloid Leukemia
December 5, 2016, ASH2016
Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing
May 2015, Nature
Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia
March 2014, PublMed
Leukemia ‘blasted’ through new drug target
July 3, 2013, A*Star Research
How I treat CML blast crisis
2012, Journal Blood
Researchers discover key reason why form of leukemia progresses from chronic phase to blast crisis
March 5, 2010, News Medical
Treatment of chronic myeloid leukemia in blast crisis
December 2008, Haematologica
Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate
January 15, 2006, PublMed
Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia
February 4, 2022, Leukemia
Matchpoint: the game is not over for blast-phase chronic myeloid leukaemia
February 2, 2022, The Lancet Haematology
Understanding and Monitoring Chronic Myeloid Leukemia Blast Crisis: How to Better Manage Patients
June 23, 2021, DovePress
Common therapeutic vulnerability for a genetically diverse and deadly leukemia
March 18, 2020, Science Daily
Researchers in Singapore find common therapeutic vulnerability for a genetically diverse and deadly leukaemia
March 17, 2020, DUKE NUS Medical School
An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
March 10, 2020, Journal Blood
Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia
February 20, 2020, Leukemia
Blast count prognostic for CML presenting in advanced phase
September 26, 2019, Medical Xpress
Pre- and post-transplant ponatinib for a patient with acute megakaryoblastic blast phase chronic myeloid leukemia with T315I mutation who underwent allogeneic hematopoietic stem cell transplantation
March 16, 2019, PubMed
TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML
April 4, 2017, NCBI
Researchers identify factors associated with survival in patients with blast phase CML
February 24, 2017, Healio
Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia
February 24, 2017, Leukemia
TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML
February 18, 2017, NCBI
MS4A3: A New Player in Leukemic Stem Cell Survival in Chronic Myeloid Leukemia
December 5, 2016, ASH2016
Novel drug candidates for blast phase chronic myeloid leukemia from high-throughput drug sensitivity and resistance testing
May 2015, Nature
Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia
March 2014, PublMed
Leukemia ‘blasted’ through new drug target
July 3, 2013, A*Star Research
How I treat CML blast crisis
2012, Journal Blood
Researchers discover key reason why form of leukemia progresses from chronic phase to blast crisis
March 5, 2010, News Medical
Treatment of chronic myeloid leukemia in blast crisis
December 2008, Haematologica
Sudden blastic transformation in patients with chronic myeloid leukemia treated with imatinib mesylate
January 15, 2006, PublMed